{"id":4804,"date":"2021-07-23T03:00:45","date_gmt":"2021-07-23T03:00:45","guid":{"rendered":"https:\/\/gd-1.com\/?p=4804"},"modified":"2024-03-20T08:31:29","modified_gmt":"2024-03-20T08:31:29","slug":"co-che-mien-dich-cua-vaccine-oxford-astrazeneca","status":"publish","type":"post","link":"https:\/\/gd-1.com\/co-che-mien-dich-cua-vaccine-oxford-astrazeneca\/","title":{"rendered":"C\u01a1 ch\u1ebf mi\u1ec5n d\u1ecbch c\u1ee7a Vaccine OXFORD-ASTRAZENECA"},"content":{"rendered":"

I. T\u1ed5ng quan v\u1ec1 vaccine AstraZeneca<\/em><\/strong><\/p>\n

T\u00ednh t\u1edbi th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i, \u0111\u1ec3 ng\u0103n ng\u1eeba s\u1ef1 l\u00e2y lan c\u1ee7a d\u1ecbch COVID-19, Vi\u1ec7t Nam \u0111\u00e3 ti\u1ebfn h\u00e0nh ti\u00eam ch\u1ee7ng cho 4,04 tri\u1ec7u ng\u01b0\u1eddi d\u00e2n, trong \u0111\u00f3 c\u00f3 kho\u1ea3ng 271 ng\u00e0n ng\u01b0\u1eddi \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u00eam \u0111\u1ee7 2 m\u0169i (t\u1ec9 l\u1ec7 0,3%). Ng\u01b0\u1eddi d\u00e2n Vi\u1ec7t Nam \u0111a ph\u1ea7n \u0111\u01b0\u1ee3c ti\u00eam b\u1eb1ng vaccine AstraZeneca, ch\u1ee7 y\u1ebfu d\u00e0nh cho c\u00e1c \u0111\u1ed3i t\u01b0\u1ee3ng t\u1eeb 18 tu\u1ed5i tr\u1edf l\u00ean.<\/p>\n

Nh\u00ecn chung, vaccine AstraZeneca ho\u1ea1t \u0111\u1ed9ng nh\u01b0 sau: c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ea5y v\u1eadt ch\u1ea5t di truy\u1ec1n c\u1ee7a virus SARS-CoV-2(ch\u00ednh l\u00e0 gai protein-S) v\u00e0o m\u1ed9t lo\u1ea1i virus v\u00f4 h\u1ea1i. Lo\u1ea1i virus v\u00f4 h\u1ea1i n\u00e0y d\u1ef1a tr\u00ean virus adeno g\u00e2y b\u1ec7nh c\u1ea3m c\u00fam \u1edf lo\u00e0i tinh tinh, \u0111\u01b0\u1ee3c \u0111\u1eb7t t\u00ean l\u00e0 ChAdOx1<\/em>. Khi m\u1ed9t ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng v\u1edbi AstraZeneca, c\u00e1c virus gi\u1ea3 mang theo gai protein-S b\u1eaft \u0111\u1ea7u ph\u00f3ng th\u00edch c\u00e1c gai n\u00e0y v\u00e0o trong c\u01a1 th\u1ec3, tr\u1edf th\u00e0nh v\u1eadt th\u1ec3 l\u1ea1 \u0111\u1ed1i v\u1edbi h\u1ec7 mi\u1ec5n d\u1ecbch. T\u1eeb \u0111\u00e2y, h\u1ec7 mi\u1ec5n d\u1ecbch nh\u1eadn \u0111\u1ecbnh c\u00e1c gai protein-S ch\u00ednh l\u00e0 k\u1ebb x\u00e2m nh\u1eadp v\u00e0 t\u1ef1 k\u00edch ho\u1ea1t c\u01a1 ch\u1ebf ph\u00f2ng th\u1ee7. \u0110\u00e2y l\u00e0 nguy\u00ean nh\u00e2n l\u00ed gi\u1ea3i cho vi\u1ec7c sau khi ti\u00eam AstraZeneca, ng\u01b0\u1eddi \u0111\u01b0\u1ee3c ti\u00eam th\u01b0\u1eddng b\u1ecb s\u1ed1t v\u00e0 m\u1ec7t m\u1ecfi, v\u00ec th\u1ef1c ra \u0111\u00e2y ch\u00ednh l\u00e0 l\u00fac h\u1ec7 mi\u1ec5n d\u1ecbch \u0111ang ho\u1ea1t \u0111\u1ed9ng \u0111\u1ec3 ti\u00eau di\u1ec7t virus gi\u1ea3 d\u1ea1ng c\u1ee7a virus COVID-19.<\/p>\n

II. C\u00e1c b\u01b0\u1edbc ch\u00ednh trong c\u01a1 ch\u1ebf ph\u00f2ng ng\u1eeba COVID-19 c\u1ee7a AstraZeneca<\/em><\/strong><\/p>\n

$\"\"$ <\/p>\n

H\u00ecnh: S\u01a1 \u0111\u1ed3 m\u00f4 t\u1ea3 c\u01a1 ch\u1ebf c\u1ee7a vaccine AstraZeneca<\/em><\/p>\n

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C\u1ea5y v\u1eadt ch\u1ea5t di truy\u1ec1n<\/em><\/li>\n<\/ol>\n
Bao ph\u1ee7 ph\u00eda ngo\u00e0i c\u1ee7a virus SARS-CoV-2 ch\u00ednh l\u00e0 c\u00e1c gai protein-S, b\u00ean trong l\u00f5i virus s\u1ebd ch\u1ee9a m\u00e3 gen c\u1ee7a gai protein-S. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u s\u1ebd t\u00e1ch 1 \u0111o\u1ea1n gen n\u00e0y v\u00e0 c\u1ea5y v\u00e0o bi\u1ebfn th\u1ec3 v\u00f4 h\u1ea1i c\u1ee7a virus adeno (l\u00e0 virus g\u00e2y c\u1ea3m c\u00fam \u1edf lo\u00e0i tinh tinh). Lo\u1ea1i virus gi\u1ea3 n\u00e0y kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng nh\u00e2n b\u1ea3n ch\u00ednh n\u00f3.<\/p>\n
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Th\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o <\/em><\/li>\n<\/ol>\n
– Sau khi \u0111\u01b0\u1ee3c ti\u00eam ch\u1ee7ng, c\u00e1c t\u1ebf b\u00e0o virus gi\u1ea3 s\u1ebd th\u00e2m nh\u1eadp v\u00e0o t\u1ebf b\u00e0o v\u00e0 b\u00e1m v\u00e0o c\u00e1c protein tr\u00ean b\u1ec1 m\u1eb7t c\u1ee7a ch\u00fang.<\/p>\n
– T\u1ebf b\u00e0o s\u1ebd bao b\u1ecdc l\u1ea5y virus gi\u1ea3, sau \u0111\u00f3 virus t\u00ecm c\u00e1ch tho\u00e1t ra ngo\u00e0i t\u1ebf b\u00e0o v\u00e0 c\u00f9ng l\u00fac \u0111\u00f3 di chuy\u1ec3n \u0111\u1ebfn nh\u00e2n, ch\u00ednh l\u00e0 khoang ch\u1ee9a DNA c\u1ee7a t\u1ebf b\u00e0o.<\/p>\n
– Virus adeno \u0111\u1ea9y DNA c\u1ee7a n\u00f3 v\u00e0o khoang t\u1ebf b\u00e0o. Tuy virus adeno kh\u00f4ng c\u00f3 kh\u1ea3 n\u0103ng nh\u00e2n b\u1ea3n, nh\u01b0ng t\u1ebf b\u00e0o c\u01a1 th\u1ec3 l\u1ea1i c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ecdc v\u00e0 sao ch\u00e9p DNA th\u00e0nh RNA t\u00edn hi\u1ec7u (message RNA)<\/em>, k\u00ed hi\u1ec7u mRNA.<\/p>\n
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T\u00e1i t\u1ea1o gai protein-S<\/em><\/li>\n<\/ol>\n
– Virus adeno c\u0169ng g\u00f3p ph\u1ea7n k\u00edch ho\u1ea1t h\u1ec7 mi\u1ec5n d\u1ecbch nh\u1eadn ra v\u1eadt th\u1ec3 l\u1ea1 trong c\u01a1 th\u1ec3 v\u00e0 s\u1eb5n s\u00e0ng \u0111\u1ec3 \u1ee9ng ph\u00f3 v\u00e0 ph\u00f2ng ng\u1eeba m\u1ea1nh m\u1ebd h\u01a1n.<\/p>\n
– Sau khi DNA \u0111\u01b0\u1ee3c t\u1ebf b\u00e0o bi\u1ebfn \u0111\u1ed5i th\u00e0nh mRNA, mRNA ti\u1ebfp t\u1ee5c \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i \u0111\u1ec3 t\u00e1i t\u1ea1o gai protein-S. M\u1ed9t s\u1ed1 gai \u0111\u1ed9t bi\u1ebfn s\u1ebd t\u1ef1 \u0111\u1ed9ng nh\u00f4 l\u00ean b\u1ec1 m\u1eb7t c\u1ee7a t\u1ebf b\u00e0o v\u00e0 m\u00f4 ph\u1ecfng l\u1ea1i h\u00ecnh d\u1ea1ng c\u1ee7a virus SARS-CoV-2.<\/p>\n
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Ph\u00e1t hi\u1ec7n k\u1ebb x\u00e2m nh\u1eadp<\/em><\/li>\n<\/ol>\n
– Khi t\u1ebf b\u00e0o \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u00eam ph\u00f2ng ch\u1ebft \u0111i, nh\u1eefng m\u1ea3nh v\u1ee5n t\u1ebf b\u00e0o ch\u1ee9a gai v\u00e0 m\u1ea3nh protein \u0111\u01b0\u1ee3c m\u1ed9t t\u1ebf b\u00e0o kh\u00e1c thu nh\u1eadn v\u00e0 t\u1ef1 g\u1eafn l\u00ean b\u1ec1 m\u1eb7t c\u1ee7a n\u00f3, g\u1ecdi l\u00e0 t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean (antigen-presenting cell).<\/p>\n
– M\u1ed9t t\u1ebf b\u00e0o kh\u00e1c, g\u1ecdi l\u00e0 t\u1ebf b\u00e0o T, khi ph\u00e1t hi\u1ec7n ra nh\u1eefng m\u1ea3nh v\u1ee1 c\u1ee7a t\u1ebf b\u00e0o ch\u1ebft s\u1ebd b\u00e1o \u0111\u1ed9ng l\u00ean h\u1ec7 mi\u1ec5n d\u1ecbch gi\u00fap nh\u1eadn di\u1ec7n v\u00e0 \u0111\u00e1nh l\u1ea1i c\u00e1c k\u1ebb x\u00e2m nh\u1eadp n\u00e0y<\/p>\n
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T\u1ea1o kh\u00e1ng th\u1ec3 v\u00e0 ng\u0103n ch\u1eb7n virus<\/em><\/li>\n<\/ol>\n
– C\u00e1c t\u1ebf b\u00e0o mi\u1ec5n d\u1ecbch kh\u00e1c (t\u1ebf b\u00e0o B) c\u00f3 th\u1ec3 va ch\u1ea1m v\u00e0o c\u00e1c gai protein-S c\u1ee7a virus gi\u1ea3 ho\u1eb7c c\u00e1c m\u1ea3nh v\u1ee1 c\u1ee7a t\u1ebf b\u00e0o ch\u1ebft ch\u1ee9a m\u1ea3nh protein v\u00e0 l\u00e0m b\u1ea5t ho\u1ea1t ch\u00fang. V\u1edbi s\u1ef1 tr\u1ee3 gi\u00fap c\u1ee7a t\u1ebf b\u00e0o T, ch\u00fang b\u1eaft \u0111\u1ea7u t\u0103ng sinh v\u00e0 ti\u1ebft ra kh\u00e1ng th\u1ec3 nh\u1eafm v\u00e0o c\u00e1c protein-S k\u1ec3 tr\u00ean.<\/p>\n
– C\u00e1c kh\u00e1ng th\u1ec3 ng\u0103n ng\u1eeba virus b\u1eb1ng c\u00e1ch kh\u00f3a c\u00e1c gai protein-S tr\u00ean b\u1ec1 m\u1eb7t \u0111\u1ec3 kh\u00f4ng c\u00e1c gai n\u00e0y ti\u1ebfp x\u00fac v\u1edbi c\u00e1c th\u1ee5 th\u1ec3 tr\u00ean ni\u00eam m\u1ea1c c\u1ee7a t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh v\u00e0 ti\u00eau di\u1ec7t ch\u00fang. \u0110\u1ed1i v\u1edbi t\u1ebf b\u00e0o \u0111\u00e3 nhi\u1ec5m b\u1ec7nh, c\u00e1c t\u1ebf b\u00e0o tr\u00ecnh di\u1ec7n kh\u00e1ng nguy\u00ean nh\u1eadn bi\u1ebft ch\u00fang b\u1eb1ng c\u00e1ch t\u00ecm t\u1ebf b\u00e0o c\u00f3 ch\u1ee9a c\u00e1c m\u1ea3nh gai protein \u0111\u00e3 b\u1ecb v\u1ee1 ra tr\u01b0\u1edbc \u0111\u00f3 v\u00e0 kh\u00f3a c\u00e1c gai th\u1ee5 th\u1ec3 l\u1ea1i.<\/p>\n
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Ghi nh\u1edb virus<\/em><\/li>\n<\/ol>\n
Vaccine AstraZeneca y\u00eau c\u1ea7u ph\u1ea3i ch\u00edch \u0111\u1ee7 2 li\u1ec1u c\u00e1ch nhau 4 tu\u1ea7n. Li\u1ec1u \u0111\u1ea7u ti\u00ean ch\u00ednh l\u00e0 d\u1ea1y cho c\u01a1 th\u1ec3 nh\u1eadn bi\u1ebft virus gi\u1ea3 th\u00f4ng qua c\u00e1c gai protein-S v\u00e0 k\u00edch ho\u1ea1t h\u1ec7 mi\u1ec5n d\u1ecbch. Li\u1ec1u th\u1ee9 2 gi\u00fap gia t\u0103ng s\u1ee9c \u0111\u1ec1 kh\u00e1ng b\u1ed5 tr\u1ee3 cho li\u1ec1u 1.<\/p>\n
III. 3 b\u01b0\u1edbc l\u01b0u \u00fd khi s\u1eed d\u1ee5ng vaccine AstraZeneca<\/em><\/strong><\/p>\n
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V\u00ec AstraZeneca s\u1eed d\u1ee5ng DNA tr\u00edch xu\u1ea5t t\u1eeb virus v\u00e0 n\u00f3 kh\u00f4ng d\u1ec3 b\u1ecb ph\u00e2n h\u1ee7y nh\u01b0 RNA, n\u00ean vi\u1ec7c vaccine kh\u00f4ng c\u1ea7n \u0111\u01b0\u1ee3c b\u1ea3o qu\u1ea3n l\u1ea1nh. Ng\u01b0\u1eddi ta d\u1ef1 \u0111o\u00e1n c\u00f3 th\u1ec3 b\u1ea3o qu\u1ea3n AstraZeneca \u00edt nh\u1ea5t 6 th\u00e1ng khi tr\u1eef l\u1ea1nh \u1edf nhi\u1ec7t \u0111\u1ed9 2-8\u00b0C.<\/li>\n
Sau khi m\u1edf l\u1ecd, vaccine n\u00ean \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng ngay trong v\u00f2ng 6 gi\u1edd.<\/li>\n
Vaccine n\u00ean \u0111\u01b0\u1ee3c ti\u00eam cho nh\u00f3m \u0111\u1ed1i t\u01b0\u1ee3ng kh\u1ecfe m\u1ea1nh t\u1eeb 18 tu\u1ed5i tr\u1edf l\u00ean v\u00e0 kh\u00f4ng m\u1eafc c\u00e1c b\u1ec7nh l\u00ed n\u1ec1n nguy hi\u1ec3m nh\u01b0 suy h\u00f4 h\u1ea5p, tim m\u1ea1ch, suy th\u1ea7n kinh v\u00e0 c\u00e1c v\u1ea5n \u0111\u1ec1 v\u1ec1 xu\u1ea5t huy\u1ebft. Kh\u00f4ng ti\u00eam vaccine cho ph\u1ee5 n\u1eef c\u00f3 thai ho\u1eb7c cho con b\u00fa.<\/li>\n<\/ol>\n
Ngu\u1ed3n:<\/em><\/strong><\/p>\n
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https:\/\/www.nytimes.com\/interactive\/2020\/health\/oxford-astrazeneca-covid-19-vaccine.html<\/a><\/li>\n
https:\/\/vnvc.vn\/astrazeneca\/<\/a><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"
I. T\u1ed5ng quan v\u1ec1 vaccine AstraZeneca T\u00ednh t\u1edbi th\u1eddi \u0111i\u1ec3m hi\u1ec7n t\u1ea1i, \u0111\u1ec3 ng\u0103n ng\u1eeba s\u1ef1 l\u00e2y lan c\u1ee7a d\u1ecbch COVID-19, Vi\u1ec7t Nam \u0111\u00e3 ti\u1ebfn h\u00e0nh ti\u00eam ch\u1ee7ng cho 4,04 tri\u1ec7u ng\u01b0\u1eddi d\u00e2n, trong \u0111\u00f3 c\u00f3 kho\u1ea3ng 271 ng\u00e0n ng\u01b0\u1eddi \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u00eam \u0111\u1ee7 2 m\u0169i (t\u1ec9 l\u1ec7 0,3%). Ng\u01b0\u1eddi d\u00e2n Vi\u1ec7t Nam \u0111a ph\u1ea7n…<\/p>\n","protected":false},"author":2,"featured_media":4805,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"rank_math_lock_modified_date":false,"footnotes":""},"categories":[40],"tags":[],"class_list":["post-4804","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tuc"],"acf":[],"_links":{"self":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/posts\/4804"}],"collection":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/comments?post=4804"}],"version-history":[{"count":7,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/posts\/4804\/revisions"}],"predecessor-version":[{"id":4837,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/posts\/4804\/revisions\/4837"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/media\/4805"}],"wp:attachment":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/media?parent=4804"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/categories?post=4804"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/tags?post=4804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}