{"id":8627,"date":"2023-06-28T04:04:24","date_gmt":"2023-06-28T04:04:24","guid":{"rendered":"https:\/\/gd-1.com\/?post_type=product&#038;p=8627"},"modified":"2024-03-13T08:21:42","modified_gmt":"2024-03-13T08:21:42","slug":"timstof-pro-2","status":"publish","type":"product","link":"https:\/\/gd-1.com\/en\/san-pham\/timstof-pro-2\/","title":{"rendered":"timsTOF Pro 2"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_69_1 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<label class=\"ez-toc-title ez-toc-toggle\" style=\"cursor:pointer\">T\u00f3m t\u1eaft n\u1ed9i dung<\/label>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #0a0a0a;color:#0a0a0a\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #0a0a0a;color:#0a0a0a\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/gd-1.com\/en\/san-pham\/timstof-pro-2\/#The_new_standard_for_high_speed_high_sensitivity_4D-Multiomics\" title=\"The new standard for high speed, high sensitivity 4D-Multiomics\">The new standard for high speed, high sensitivity 4D-Multiomics<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/gd-1.com\/en\/san-pham\/timstof-pro-2\/#Dual-TIMS_and_CCS-enabled_analysis\" title=\"Dual-TIMS and CCS-enabled analysis\">Dual-TIMS and CCS-enabled analysis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/gd-1.com\/en\/san-pham\/timstof-pro-2\/#PASEF%C2%AE\" title=\"PASEF\u00ae\">PASEF\u00ae<\/a><\/li><\/ul><\/nav><\/div>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"The_new_standard_for_high_speed_high_sensitivity_4D-Multiomics\"><\/span><strong>The new standard for high speed, high sensitivity 4D-Multiomics<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<div class=\"responsivegrid aem-GridColumn--default--none aem-GridColumn--phone--none aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--phone--0 aem-GridColumn--offset--default--0\">\n<div class=\"aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--phone--12 \">\n<div class=\"ui-typography--richtext aem-GridColumn--phone--12 aem-GridColumn aem-GridColumn--default--6\">\n<div class=\"aem-text\">\n<div class=\"ui-typography--richtext\">\n<p>Liquid chromatography (LC) coupled with mass spectrometry (MS) has become the gold standard in various omics fields. However, the coverage of proteomes or metabolomes in complex biological samples remains challenging due to limited speed, sensitivity and resolution of current mass spectrometers.<\/p>\n<p>Adding trapped ion mobility spectrometry (TIMS) to the equation unlocks the parallel accumulation serial fragmentation (PASEF<sup>\u00ae<\/sup>) acquisition method to provide extremely high MS\/MS speed and sensitivity, requiring minimal sample amounts.<\/p>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"Dual-TIMS_and_CCS-enabled_analysis\"><\/span><strong>Dual-TIMS and CCS-enabled analysis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>TIMS is first and foremost a separation technique in the gas phase. This resolves sample complexity through an added dimension of separation in addition to high performance liquid chromatography (HPLC) and mass spectrometry, increasing peak capacity and confidence in compound characterization.<\/p>\n<p>Equally important, the TIMS device also accumulates and concentrates ions of a given <i>m\/z<\/i> and mobility, enabling a unique increase in sensitivity and speed.<\/p>\n<p>A near 100% duty cycle can be achieved with the dual-TIMS technology facilitating accumulation in the front section, while ions in the rear section are sequentially released depending on their mobility. This process of parallel accumulation serial fragmentation (PASEF<sup>\u00ae<\/sup>) enables collisional cross section (CCS) analysis.<\/p>\n<figure style=\"width: 667px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-pro-2\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns_441919867\/contentpar-2\/image.coreimg.82.1280.jpeg\/1621522317839\/timstof-noise-reduction.jpeg\" alt=\"\" width=\"667\" height=\"267\" \/><figcaption class=\"wp-caption-text\">CCS-enabled analysis opens up many further analytical possibilities, from greater certainty of compound identification to confident library matching and lower false discovery rates (FDRs) in large datasets.<\/figcaption><\/figure>\n<h3 class=\"ui-typography--h2\"><span class=\"ez-toc-section\" id=\"PASEF%C2%AE\"><\/span><strong>PASEF<sup>\u00ae<\/sup><\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/www.bruker.com\/en\/products-and-solutions\/mass-spectrometry\/timstof\/timstof-pro-2\/_jcr_content\/root\/sections\/features\/sectionpar\/twocolumns_2024759839\/contentpar-1\/image.coreimg.82.1280.jpeg\/1661504108604\/pasef-circle.jpeg\" width=\"477\" height=\"308\" \/><\/p>\n<p>The timsTOF Pro 2 comes with our innovative dual-TIMS analyzer that offers three times higher ion capacity. Simplified ion optics maximize ion transfer and sensitivity to set a new standard in 4D-Multiomics. PASEF<sup>\u00ae<\/sup>\u00a0is a redesigned MS\/MS technology to meet speed requirements of omics applications. Ions are separated using trapped ion mobility spectrometry, eluted (~ 100 ms) and detected in the quadrupole time of flight (QTOF), generating the TIMS MS heat map. PASEF<sup>\u00ae<\/sup>\u00a0then uses the same TIMS separation to serially fragment ions. The quadrupole isolates a certain ion species during its elution for MS\/MS and immediately shifts to the next precursor. Parent and fragment spectra are aligned by mobility values. The timsTOF Pro 2 can achieve a sequencing speed of &gt; 120 Hz in PASEF<sup>\u00ae<\/sup>\u00a0mode. Furthermore, the MS\/MS spectra quality of low abundant analytes can be enriched by selecting them several times.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>The timsTOF Pro 2, powered by the latest parallel accumulation serial fragmentation (PASEF<sup>\u00ae<\/sup>) technology, paves the way for 4D-Multiomics applications. With its proven robustness, high sensitivity and fast MS\/MS acquisition, timsTOF Pro 2 is the platform of choice for 4D-Proteomics, 4D-Metabolomics and 4D-Lipidomics.<\/p>\n","protected":false},"featured_media":8629,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"rank_math_lock_modified_date":false},"product_cat":[1404],"product_tag":[2634,2684],"class_list":{"0":"post-8627","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-timstof","7":"product_tag-bruker-en","8":"product_tag-timstof-pro-2-en","9":"yith_product_brand-bruker-en","11":"first","12":"instock","13":"shipping-taxable","14":"product-type-simple"},"acf":[],"_links":{"self":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/product\/8627"}],"collection":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/comments?post=8627"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/media\/8629"}],"wp:attachment":[{"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/media?parent=8627"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/product_cat?post=8627"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/gd-1.com\/wp-json\/wp\/v2\/product_tag?post=8627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}