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Krios G4 Cryo – Transmission Electron Microscopy (TEM)

The Krios G4 Cryo-TEM is a 300 kV cryo-transmission electron microscope engineered to enable 3D visualization of proteins and molecular machines at atomic level, their localization, and dynamics within the architecture of the biological cell.

Atomic resolution cryo-EM with enhanced productivity and compact design

The award-winning Thermo Scientific Krios G4 Cryo-Transmission Electron Microscope (Cryo-TEM) enables you to unravel life at the atomic level—easier, faster, and more reliably than ever before. The most compact TEM in its class, the Krios G4 Cryo-TEM consists of a highly stable 300 kV TEM platform and the industry-leading Autoloader (a cryogenic sample manipulation robot), making it ideally suited for automated applications such as cryo-electron tomography (cryo-ET), single-particle analysis (SPA), and micro-electron diffraction (MicroED).

The Thermo Scientific Falcon 4i Direct Electron Detector in 4 minutes

The Falcon 4i Direct Electron Detector is 30% faster while maintaining unsurpassed imaging quality with high detective quantum efficiency. Lossless data compression with Electron Event Representation and improved throughput increases productivity.

Krios Cryo-TEM Fringe-Free Imaging 

Acquire more images per sample area with fringe-free imaging (FFI), enhancing your daily data throughput.

Smart EPU Software for single particle analysis data collection

Smart EPU Software is an innovative, easy-to-use data acquisition solution or ecosystem for single particle analysis that focuses on automation and user guidance to increase throughput and deliver reproducible results.

Krios Cryo-TEM Aberration-Free Image Shift

Aberration-free image shift (AFIS) is an optical mode for faster data acquisition without comprising image quality. AFIS performs large beam shifts without off-axis coma and astigmatism.

Insights into protein function only cryo-EM can provide

The award-winning Thermo Scientific Krios G4 Cryo-TEM is a 300 kV cryo-transmission electron microscope engineered to enable 3D visualization of proteins and molecular machines, their localization, and dynamics within the architecture of the biological cell for unmatched biological insights.

Atomic resolution single particle analysis

Using a Krios G4 Cryo-TEM equipped with a Thermo Scientific Selectris X Imaging Filter, structural biologists achieved record-breaking resolution results, featured on the cover of Nature and other recent articles from Science and Nature. Scientists from the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, obtained a 1.2 ångström resolution structure of the iron-storing protein apoferritin. They also achieved a 1.7 ångström resolution of membrane protein (GABA receptor), with an even sharper resolution in key parts of the protein. This human membrane protein has target sites for general anesthetics, benzodiazepines, barbiturates, and neuroactive steroids, making it very relevant to structure-based drug discovery. In addition to the resolution leap, the Selectris technology can also significantly impact productivity. By having a better filter and camera, you can achieve a specific resolution with much less data

Cellular cryo-tomography

The Krios G4 Cryo-TEM offers best in class cryo-electron tomography (cryo-ET) capabilities, providing nanometer-scale imaging of a cell’s interior in 3D and the visualization of protein complexes within their physiological environments. Using the Krios Cryo-TEM, tomography data can be obtained from whole bacterial cells or lamellae prepared with Thermo Scientific Aquilos, Arctis or Hydra Bio focused ion beam (Cryo-FIB) instruments.